The MIVM Mixers & Mixer Stand
The Confined Impinging Jet (CIJ) and the Multi Inlet Vortex Mixer (MIVM)
In collaboration with the Department of Chemical and Biological Engineering at Princeton University, Holland Applied Technologies fabricates the Confined Impinging Jet (CIJ) and Multi Inlet Vortex Mixer (MIVM) mixers. The Confined Impinging Jet (CIJ) and Multi Inlet Vortex Mixer (MIVM) mixers have been designed and characterized in research led by Prof. Robert Prud’homme at Princeton University. His research group has produced a number of articles highlighting their use in the production of nanoparticles using scalable processing techniques.
Additional Information
The application of nanoparticles in modern medicine is a rapidly developing field of study. Nanoprecipitation is a common fabrication technique used for encapsulation of both hydrophilic (i.e. having a tendency to mix with, dissolve in, or be wetted by water) and hydrophobic (i.e. tending to repel or fail to mix with water) drugs in nanoparticles. Flash NanoPrecipitation (FNP) provides a simple, rapid and scalable technique to form these drug nanoparticles.
The Confined Impinging Jet (CIJ) is the simplest mixer design for FNP and permits mixing of two streams in a scalable and continuous fashion.
Multi Inlet Vortex Mixer (MIVM)
The Multi Inlet Vortex Mixer (MIVM) was also developed to enable up to four different stream inputs while still achieving the rapid micromixing required for uniform particle formation. The MIVM requires a mixer stand to enable uniform depression of the syringes.
What Our Customers Have to Say…
“Holland will put in the time and effort up front to fully comprehend complex processes, resulting in a system that meets, and frequently surpasses, expectations.”
Process Engineer – Pharmaceutical Contract Manufacturer
“Holland has been a reliable partner for many years. They have the ability to support our business thru their vast inventory of repair components, onsite field service and new replacement components. Holland has been proactive in providing recommendations for repair kits as well as carrying safety stock at their facility to support our specific needs.”
Operations Manager – Food Processing Facility
“Holland understands our need for not only quality products, but the detailed documentation and material traceability required in the pharmaceutical industry. We’ve used their Document Locator tool to help manage documentation for our production equipment. It’s been great to have a historical record of documentation covering our long-term relationship.”
Quality Manager – OEM of Single Use Biotech Equipment
““Holland Applied is a business partner that I find to be highly trustworthy, competent, and customer focused. We keep using them for our machining and fabrication needs because we know we can rely on them to provide high-quality goods on time and at competitive market prices.”
Head of Procurement – Injectable Drug Manufacturer
