Single-Use Manifolds

Sterile Sampling & Process Assemblies for Biopharma & CDMOs
Holland Applied Technologies designs and manufactures high-quality single-use sampling manifolds and tubing assemblies engineered for sterile performance, GMP documentation, and scalable production.  Our assemblies support upstream and downstream bioprocessing, helping to reduce contamination risk, improve repeatability, and simplify validation.

Applications & Use Cases

Single-use manifolds support critical sampling and process functions across biopharma operations:

  • Bioreactor sampling (SUB & stainless systems)
  • TFF / UF / DF filtration
  • Harvest and clarification sampling
  • Buffer and media addition
  • Final drug substance sampling
  • Integrated transfer and process manifolds
  • Multi-site process standardization

Engineering & Product Capabilities

Holland provides configurable, sterile tubing assemblies designed for performance and compatibility:

  • Multi-branch sampling manifold configurations
  • Closed-system sterile access designs
  • Aseptic connectors and sampling ports
  • Weldable thermoplastic tubing options
  • Integration with filtration systems and process equipment
  • Standardized or custom-configured assemblies
  • Compatibility with common tubing materials (C-Flex®, silicone, TPE)

Quality, Documentation & Scalability

Built for GMP environments with controlled processes and repeatability:

  • Controlled drawings and revision management
  • Lot traceability and material certifications
  • QA inspection records and documentation packages
  • Change control discipline
  • Repeatable BOMs for standardized builds
  • Support for qualification and validation readiness
  • Multi-site deployment support

Single-Use Manifolds Products

Need Expert Advice on Your Application?

Our team of experts can assist you in specifying and sizing the best quality, most cost-effective solution for your application.

What Our Customers Have to Say…

“Holland will put in the time and effort up front to fully comprehend complex processes, resulting in a system that meets, and frequently surpasses, expectations.”

Process Engineer – Pharmaceutical Contract Manufacturer

“Holland has been a reliable partner for many years. They have the ability to support our business thru their vast inventory of repair components, onsite field service and new replacement components. Holland has been proactive in providing recommendations for repair kits as well as carrying safety stock at their facility to support our specific needs.”

Operations Manager – Food Processing Facility

“Holland understands our need for not only quality products, but the detailed documentation and material traceability required in the pharmaceutical industry. We’ve used their Document Locator tool to help manage documentation for our production equipment. It’s been great to have a historical record of documentation covering our long-term relationship.”

Quality Manager – OEM of Single Use Biotech Equipment

““Holland Applied is a business partner that I find to be highly trustworthy, competent, and customer focused. We keep using them for our machining and fabrication needs because we know we can rely on them to provide high-quality goods on time and at competitive market prices.”

Head of Procurement – Injectable Drug Manufacturer

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