Single-use technologies are playing a key role in the reduction in risk of cross contamination in addition to time and cost benefits associated with assembly, cleaning and cleaning validation. Bio-Simplex™ Sterile Bottle Assembly Systems are available in a range of commonly used sizes from 60mL to 2 Liter. Each single-use sample bottle includes a 2 port EZ Top® Closure, made from C-Flex® pharmaceutical grade thermoplastic elastomer (TPE) resin and tubing, engineered to ensure an unobstructed fluid path, extremely low levels of extractables and a secure elastomeric seal between bottle and cap surfaces. Each system is equipped with a PETG bottle (2 Liter is poly-carbonate), a 0.2 ?m vent filter, an 18” length of 1/8”ID x 1/4”OD C-Flex tubing with a plug end, notched dip tube to the bottom of the bottle and a polyethylene cap (polypropylene on 2 Liter). Economically designed for the single-use market, sample bottle assemblies are easily used with sterile connecting devices and thermal tubing sealers.

Bio-Simplex™ Sterile Bottle Assembly Systems are sold as single items, each double bagged and gamma irradiated for a Sterility Assurance Level (SAL) of 10-6. Customer-generated designs, sizes, packaging and other options –– such as connectors, heat-sealed ends or alternate materials –– are available as custom orders.

The Bio-Simplex™ Carboy Closure System features an EZ Top® Closure Assembly made from C-Flex® pharmaceutical grade resin and tubing, engineered to ensure an unobstructed fluid path, extremely low levels of extractables and a secure elastomeric seal against plastic, glass and metal surfaces. The EZ Top® Assembly includes C-Flex® tubing with standard plug end fittings, a Bio-Simplex™ Flex Joint™, 0.2 ?M vent filter and cap. Economically designed for single use, the Bio-Simplex™ Carboy Closure System eliminates cleaning and contamination from repeated use. It is easily used with sterile connecting devices and thermal tubing sealers.We offer standard 2 and 3 port configurations to fit a wide variety of carboys in sizes from 5 to 20 Liters.

Available as a complete packaged Bio-Simplex™ Carboy Closure System (EZ Top® Assembly, carboy and cap), either gamma irradiated or non-irradiated; or as individually packaged EZ Top® Closure Assemblies. Custom designs, materials, sizes, packaging and other options––such as quick disconnect devices, Luer connections, heat-sealed ends or alternate carboy materials––are available on request.

Saint Gobain now offers the Bio-Simplex™ Polypropylene Carboys for advanced liquid handling and solution storage for many pharma applications. Saint-Gobain offers four popular sizes of carboys: 5 L, 10 L, 20 L and 40 L manufactured from high quality polypropylene, which is resistant to chemicals . Many times, users autoclaving plastic carboys experience deformities/collapsing from elevated temps. Not with these. The Bio-Simplex carboys can withstand sterilization temperatures up to 275°F (135°C)

The carboy’s body includes design features that allow the user to easily hold, lift, fill, and pour while the versatile Container closure technology provides interchangeable and leak-proof topconnections. The Bio-Simplex carboys are available with or without an autoclavable spigot. They also feature easy-to-read certified graduation marks with ± 5% accuracy, large molded marks for clearly identifiable volume and material. The Bio-Simplex system–carboy, cap, and spigot is autoclavable.

Additionally, a Bio-Simplex Container Closure can be added to create a complete container assembly when combined with cap and container. This economical assembly, designed for single use, can successfully replace stainless steel closures and eliminate costs such as cleaning, validation and assembly, and the contamination from repeated use.

Economically designed for the single-use market, Bio-Simplex™ Sampling Manifold Systems are available with either four, six, eight or ten 60mL sampling bottles and an additional 500mL purge bottle at the end of the manifold. Each 60mL PETG bottle is connected to the Bio-Simplex™ manifold with 10 inches of tubing with a clamp, an EZ Top® container closure, a 0.2 ?m vent filter and polyethylene cap. All EZ Top®s, tubing and manifolds are made from animal derived component free (ADCF) pharmaceutical grade C-Flex® thermoplastic elastomer (TPE) resin –– engineered to ensure an unobstructed fluid path, a secure elastomeric seal against each bottle with extremely low levels of extractables.

Bio-Simplex™ Sampling Manifolds are easily used with sterile connecting devices and thermal tubing sealers. They are sold double bagged and gamma irradiated. A carrying traydesigned for up to ten 60mL sample bottles and one 500mL purge bottle is included.

Bio-Simplex Sampling Manifolds Ideal Applications

The standard 4, 6, 8 or 10 bottle sampling manifolds provide ideal solutions for aseptic sampling, sterile additions, and for pulling samples to be retained. In the typical cell culture application, using the system provides a simple and easy mechanism for taking daily or periodic samples without breaking into the production line. This system also provides an ideal method to pull batch samples in the final formulation of your product. This sales literature provides details on our standard Sampling Manifold line. If you have a specific application that requires some modification or customization please call us and let us know your application.

Single-use technologies are playing a key role in the reduction in risk of cross contamination in addition to time and cost benefits associated with assembly, cleaning and cleaning validation. Bio-Simplex™ Spinner Flask Accessories are designed to allow user to maintain their current investment in glassware, but with the convenience of a single-use filling assembly. Molded one piece construction creates a seamless fluid path and unobstructed inner bore, eliminates contamination and product loss due to loose connections. The assembly includes:

1.) an EZ Top® stopper, made from C-FLex® pharmaceutical grade animal derived component free (ADCF) thermoplastic elastomer (TPE) resin and tubing to insure an unobstructed fluid path, extremely low levels of extractables and provide an elastomeric seal against glass, plastic and metal surfaces.

2.) a Bio-Simplex™ FlexJoint™ which uses a patent-pending design and construction to accommodate angle deviation in hand blown spinner flasks and eliminate tube kinking and shape loss after autoclaving.

3.) a polypropylene cap. Bio-Simplex™ Spinner Flask Accessories are easily used with sterile connecting devices and thermal tubing sealers.

We offer standard 2 and 3 port configurations in 1, 3, 8, 15 and 36 Liter sizes, sold as single items. All are autoclavable.

Customer-generated designs, sizes, packaging and other options –– such as connectors, heat-sealed ends or alternate materials –– are available as custom orders.

The number one choice of the biopharmaceutical industry in single-use Erlenmeyer Flask assemblies, Bio-Simplex Erlenmeyer Flask Closures are now available solo (Closure Assembly) or with a standard polycarbonate flask (System). The Bio-Simplex Erlenmeyer Flask Closure Assembly features the EZ Top® assembly,made from pharmaceutical grade C-Flex® thermoplastic elastomer (TPE) resin and tubing, and is engineered to ensure an unobstructed fluid path, extremely low levels of extractables and a secure elastomeric seal against plastic, glass and metal surfaces.

The Erlenmeyer Flask Closure Assembly includes C-Flex® tubing with a choice of either male Luer connections or CPC®quick disconnect fittings, a Bio-Simplex FlexJoint, 0.2 ?m vent filter and polypropylene cap. Economically designed for the single use market, both the Bio-Simplex™ Assembly and System eliminate cleaning and contamination from repeated use. They are easily used with sterile connecting devices and thermal tubing sealers. Standard configurations include 2 port configurations in 1, 2 and 3 Liter sizes, available as individually packaged Bio-Simplex Closure Assemblies or a complete packaged Bio-Simplex Erlenmeyer Flask System (Bio-Simplex™ Assembly, Erlenmeyer Flask and cap). Both come gamma irradiated.

Customer-generated designs, sizes, packaging and other options –– such as connectors, heat-sealed ends or alternate materials –– are available as custom orders.