Quite simply, a sterile connection allows for the dry connection of two separate pathways, while maintaining the independent sterile integrity of both sides. Typical applications might include: the connection to a disposable bag from a bulk tank, mixing of two different types of media together or even simply entering a clean area from a non-clean environment

Holland Applied Technologies provides many different types of mixers for both food and pharmaceutical use. We have listed some of the more common mixers available on the market.

While all silicone tubing looks very similar from a few feet away, there are inherent differences separating the field.  A [...]

There are many different types of sanitary pumps used in the pharmaceutical and food industries. Some of these types include centrifugal, Rotary Lobe, Double Diaphragm, Peristaltic and Piston type pumps. Holland Applied Technologies sells each of the different types of pumps above for a myriad of applications.

Holland Applied Technologies participates in the ASME BPE Standards Subcommittees.  Many people involved in the Biotech and Pharmaceutical industries may [...]

The two dissimilar materials; the elastomer and the stainless steel disc expand and contract at different rates during temperature changes causing deformation and separation.This area of separation is virtually impossible to clean.

As you can see, there is now more than one way around the utilization of a flow hood in bioprocessing. Making sterile connections on the fly allows for a number of efficiency improvements – as evidenced by the rapidly growing trend in the biopharmaceutical/biotech industry.

A Contract Manufacturer can save the capital cost of buying new stainless steel vessels each time by purchasing one Single Use System.

While PTFE, FEP and other fluoropolymer based materials are not recommended for gamma irradiation, most other components can.

Now the bleach tank and all the smaller buckets are changed to Polypropylene. All the troublesome piping has been replaced with a single molded silicone tubing assembly. The flow is controlled with a "non-product contact" stainless steel pinch style valve.

He determined that the strainers were being damaged with an aggressive back flushing process. He proposed alternative Wedgewire strainers manufactured by Sani-Matic that could be aggressively back flushed.

because there are a number of specific disadvantages which render silicone hose unsuitable in some applications.

The order was placed and valves pulled from in house stock ITT diaphragm valves to be ported and mechanically polished in house at Holland. The ITT valves were electropolished, passivated and delivered to the customer within four days.

This month Holland Applied provided (3) customers jacketed sanitary tube assemblies one to two days after receipt of orders.

The Pharmaline hose is a smooth inner bore Teflon hose with tight convolutions on the OD of the Teflon liner allowing a tighter bend radius without kinking.